Adhesion and proliferation of living cell on surface functionalized with glycine nanostructures
نویسندگان
چکیده
Abstract This research presents the application of glycine amino acid for establishing firm cell‐substrate interaction instead expensive adhesion proteins, peptides and peptide derivatives. The is chemically functionalized on coverslip to achieve self‐assembled nanostructure. Glycine self‐assembly NaCl treated coverslips initiated with SiONa + :COO − linkage while their nanostructure achieved formation chain through NH 3 covalent between adjacent molecules. functionalization steps are confirmed by Fourier‐transform infrared spectroscopy (FTIR) investigation. atomic force microscopy (AFM) scanning electron (SEM) investigations reveal that growth initiates at 4 Hours (H) post‐treatment maximum appears after 8H‐10H. Both vertical horizontal nanostructures show dependence periods. Various levels surface different baby hamster kidney (BHK‐21) cell proliferation efficiency performance 10H surface. shows negligible difference when compared glycine‐aspartic (RGD) Finally, curves obtained from both RGD exponential phage up 48H followed stationary 72H death many cells 96H. Thus, this concluded equally effective proliferation.
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ژورنال
عنوان ژورنال: Nano select
سال: 2021
ISSN: ['2688-4011']
DOI: https://doi.org/10.1002/nano.202100043